Ro 10-5824 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ro 10-5824 dihydrochloride is a selective agonist of dopamine D4 receptor partial, (Ki of 5.2 nM).

Ro 10-5824 dihydrochloride is a selective agonist of dopamine D4 receptor partial, (Ki of 5.2 nM).(In Vitro):RO-10-5824 shows high affinity binding(Ki=5.2±0.9 nM (n=3)), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding (EC50 : 205±67 nM) (n=7) and maximal induction at 36±4% above basal level. (In Vivo):The success rate in the ORD task increased by Ro 10-5824 (3 mg/kg). At doses of 1 and 3 mg/kg, in the frontal cortex, Ro 10-5824 increases baseline gamma band activity. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice.

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GPCR/G Protein

Dopamine Receptor

Human Endogenous Metabolite

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189744-94-3

353.3

C17H22Cl2N4

>98% (HPLC)

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Cl.Cl.Cc1ncc(CN2CCC(=CC2)c2ccccc2)c(N)n1

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(-20℃)

With Ice Pack

≥ 2 years